Os terpenos possuem propriedades antibacterianas e o ácido rosmarínico possui atividades antioxidante, anti-inflamatória e antimicrobiana. Thus, this systematic review aimed to examine and synthesize the knowledge on the antitumor effects of carvacrol and thymol. However, the fragmentation of internucleosomal DNA and the initial apoptotic determinants were observed only in the cell line 5RP7 cell line. It triggers apoptosis by forming pores within the outer mitochondrial membrane, releasing cytochrome C that activates proteases such as caspase-9 and -3, that dismantle and destroy the cell (apoptosis) (Olsson and Zhivotovsky, 2011). (2009). (2017). Os valores de MIC90 variaram entre 0,015 e 0,03% (146-292 μg/mL) para as bactérias Gram-positivas e P. mirabilis. Similarly, Melušová et al. In Asia, the continent with the largest number of publications on the subject, the use of traditional, popular medicine continues to grow (De Boer and Cotingting, 2014) due to the low costs, easy access, the frequent reduced side effects and toxicity, and their better biodegradable properties (Soković et al., 2013). Med. SYRCLE's Risk of Bias Tool for Animal Studies. In vitro, carvacrol appears to be more potent than thymol. Infect. Carvacrol and Rosemary Essential Oil Manifest Cytotoxic, DNA-Protective and Pro-apoptotic Effect Having No Effect on DNA Repair. doi:10.1517/14728222.2014.961425, Kim, C., and Kim, B. Studies showed that phosphorylation/activation of p38, MAPK and JNK contributes to cancer cell apoptosis (Liu et al., 2014; Wang et al., 2014) and that the p38 regulates apoptosis process, cycle growth progression and cell differentiation (Zarubin and Han, 2005; Krens et al., 2006). Chan WY, Hickey EE, Khazandi M, Page SW, Trott DJ, Hill PB. 387, 95–105. doi:10.3109/14756366.2016.1161620, Jamali, T., Kavoosi, G., Safavi, M., and Ardestani, S. (2018). Anti-Cancer Natural Products and Their Bioactive Compounds Inducing ER Stress-Mediated Apoptosis: A Review. Biophysical Res. Federal government websites often end in .gov or .mil. Arch. Please enable it to take advantage of the complete set of features! Rev. El carvacrol del aceite de orégano es un antioxidante con efecto anticancerígeno, sobre todo ante el cáncer de colon.En la Universidad Harbin (China) se estudia incluso su uso como agente terapéutico. 59, 125–132. Expert Opin. Available at: http://www.who.int/publications/10-year-review/en/ (Acesseced November 20, 2020). This site needs JavaScript to work properly. PC-3 cells also exhibited cytotoxicity and decreased cell viability in a concentration dependent manner after carvacrol treatment (Horng et al., 2017). Palabras clave: Aceite esencial, Timol, Carvacrol, Orégano, Origanum, HS-SPME-GC-MS. Recibido: 17/08/2020 The uncontrolled proliferation of cancer cells occurs due to their ability to prevent programmed cell death (apoptosis) (Olsson and Zhivotovsky, 2011; Dabrowska et al., 2016; Kim and Kim, 2018), that is responsible for eliminating aberrant proliferating cells or those with DNA damage/mutations (Dabrowska et al., 2016) (Figure 5). 3. Carvacrol was more cytotoxic compared to thymol (Jamali et al., 2018), α-thujone, 4-terpineol, 1,8-cineol, bornyl acetate and camphor (Tayarani-Najaran et al., 2019). doi:10.1155/2018/9049252, Wang, Y., He, Q.-Y., and Chiu, J.-F. (2014). É um óleo espesso que assenta a 20 °C numa massa de cristais com ponto de fusão 0 °C, e ponto de ebulição 236–237 °C. Of these, three were excluded after reading the full text (two for presenting the same results and one that tested the anti-cancer effect on bacteria) and four for not having access to the full text, resulting in 70 articles. Costuma sofrer com dores de cabeça ou enxaquecas? Se realizó un ensayo de cinética de tiempo de destrucción para confirmar la actividad bactericida y fungicida de los aceites y sus componentes fenólicos. The History of Medicine. (2018). introducción la determinación de timol y carvacrol en muestras de orégano y otras plantas, ha sido realizado por muchos autores utilizando métodos por hplc 1-5 y cromatografía de gases con detector fid o de masas. In this systematic review, only one in vivo study (10%) reported a decrease in the levels of MMP-2 and MMP-9 in liver cancer after treatment with carvacrol (Subramaniyan et al., 2014), the majority 8.6% (n = 6) were in vitro studies. Likewise, there was an increased expression of the death-associated protein kinase 1 (DAPK1) and decreased expression of serine/threonine-protein phosphatase 2A (PPP2R2A) in tumor tissues (Li et al., 2019). The original contributions presented in the study are included in the article/Supplementary Material, further inquiries can be directed to the corresponding author. Pharm. Med. 12, 133. doi:10.1007/s11655-020-3193-5, Martino, E., Casamassima, G., Castiglione, S., Cellupica, E., Pantalone, S., Papagni, F., et al. Estos aceites esenciales y sus principales componentes fenólicos tienen el potencial de ser investigados in vivo para el tratamiento de la otitis externa canina. The induction of PC-3 cells apoptosis was mostly through the intrinsic pathway, associated with the production of ROS and mediated by the increase expression of caspase-3, -8 and -9 and Bcl-2/Bax. 5. “Dietary Phytochemicals, Epigenetics, and Colon Cancer Chemoprevention,” in Epigenetics of Cancer Prevention. doi:10.1007/s11033-019-05216-5, Alzahrani, A. S. (2019). Received: 29 April 2021; Accepted: 22 June 2021;Published: 07 July 2021. 4. (2016). Neoplasma 61 (6), 690–699. Detailed description of the studies that used thymol, included in the systematic review. Oral Pathol. é conhecido por suas propriedades antibacterianas, especialmente no controle das bactérias escherichia coli (responsável muitas vezes por infecções no trato gastrointestinal e urinário) e bacillus … Food Chem. Inflammopharmacol 27 (6), 1275–1283. ACEITE DE ORÉGANO 150 MG: Nuestro Aceite de Orégano contiene Carvacrol, Timol y otros Terpenos, antisépticos y antioxidantes naturales, que promueven la Salud Digestiva y Respiratoria. The development of this method is essential to provide tools for decision making to identify regions where one or more ecotypes can potentially grow and produce high quality of essential oils contents of thymol and carvacrol. Concise Review: Regulation of Embryonic Stem Cell Lineage Commitment by Mitogen-Activated Protein Kinases. Esta reacción tiene lugar en fase gaseosa. J. Pharmacol. Targets 19 (1), 113–127. doi:10.1038/cdd.2011.30, Ouzzani, M., Hammady, H., Fedorowicz, Z., and Elmagarmid, A. doi:10.1016/j.molmed.2017.02.001, Ghavami, S., Hashemi, M., Ande, S. R., Yeganeh, B., Xiao, W., Eshraghi, M., et al. Determinación de timol y carvacrol en una matriz orgánica de alimento . Available at: https://www.springer.com/gp/book/9781588297488 (Acesseced December 21, 2020). Thus, inhibition of the PI3K/Akt/mTOR signaling pathway may be a possible mechanism involved behind the effects of thymol on HL-60 cells (Pathania et al., 2013). Moreover, further animal studies should be encouraged, as they have as yet made limited progress, and most of the current results are based on in vitro studies. MMP‐2 and MMP‐9 as Prognostic Markers for the Early Detection of Urinary Bladder Cancer. In this review, 33.3% (n = 23) of in vitro studies reported an increase of caspase activity, more specifically caspase-3 (Deb et al., 2011; Liang and Lu, 2012; Yin et al., 2012; Ferraz et al., 2013; Liang et al., 2013; Al-Fatlawi and Ahmad, 2014; Chen et al., 2015; Bhakkiyalakshmi et al., 2016; Khan et al., 2017; Li et al., 2017; Abbas and Al-Fatlawi, 2018; Chauhan et al., 2018; Günes-Bayir et al., 2018; Günes-Bayir et al., 2018; Tayarani-Najaran et al., 2019), -6 (Al-Fatlawi and Ahmad, 2014; Abbas and Al-Fatlawi, 2018), -7 (Kang et al., 2016), -8 (Deb et al., 2011; Pathania et al., 2013; Kang et al., 2016; Khan et al., 2019) and -9 (Deb et al., 2011; Pathania et al., 2013; Al-Fatlawi and Ahmad, 2014; Kang et al., 2016; Li et al., 2017; Abbas and Al-Fatlawi, 2018; Günes-Bayir et al., 2018; Günes-Bayir et al., 2018; Potočnjak et al., 2018; Khan et al., 2019). (2020). doi:10.1002/jcp.27054, Lin, S.-C., Lo, S.-S., Liu, C.-J., Chung, M.-Y., Huang, J.-W., and Chang, K.-W. (2004). Multiresistente Pathogene stellen eine große globale Herausforderung bei der antimikrobiellen Therapie dar und verkomplizieren häufig eine Otitis externa von Hunden. Li et al. (2016). Método: el aceite esencial se obtuvo por hidrodestilación e hidrodestilación asistida por radiación con microondas, a partir de las hojas; se determinó densidad relativa a 20 . doi:10.4077/CJP.2017.BAF447, Yin, Q.-h., Yan, F.-x., Zu, X.-Y., Wu, Y.-h., Wu, X.-p., Liao, M.-c., et al. Our review identified a considerable number of reports (77 studies) published in the last two decades, with an increasing trend over recent years. FREE delivery Fri, Dec 16 on $25 of items shipped by . The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. 22 (3), 534–540. Regarding thymol (50 µM), the KG1 cell line was also more sensitive when compared to the other two and at the 100 µM dose, thymol was able to induce complete cell death in the KG1 and HL60 cell lines (Bouhtit et al., 2021). Bogotá Colombia. Zehra A, Wani SM, Jan N, Bhat TA, Rather SA, Malik AR, Hussain SZ. Para cada nivel se realizó la determinación por triplicado en el equipo de HPLC. El carvacrol es un compuesto químico que se encuentra en los aceites esenciales de la mejorana, el orégano, el tomillo, la ajedrea y otras plantas. Drug Chem. Pharmacol. doi:10.1515/chem-2020-0011, Balan, D. J., Rajavel, T., Das, M., Sathya, S., Jeyakumar, M., and Devi, K. P. (2021). Como se muestra en la imagen de arriba, la estructura química del carvacrol contiene un grupo metilo. (2014). doi:10.26226/morressier.5770e29ad462b80290b4ba57, Melušová, M., Jantová, S., and Horváthová, E. (2014). Further studies are required to help unravel and define the mechanisms of action of the two compounds against cancer cells, as well as studies that further explore their chemopreventive and anti-metastatic effects. Medicinal Plants for Women's Healthcare in Southeast Asia: A Meta-Analysis of Their Traditional Use, Chemical Constituents, and Pharmacology. Commun. Este compuesto tiene un olor aromático agradable, y podemos extraerlo de varias plantas como un sólido cristalino blanco. Boucher HW, Talbot GH, Bradley JS et al. (2016). } Targeting Vascular Endothelial Growth Factor and Angiogenesis for the Treatment of Colorectal Cancer. doi:10.1038/modpathol.3800066, Georgakilas, A. G., Martin, O. Sci Rep. 2022 Oct 8;12(1):16923. doi: 10.1038/s41598-022-20751-1. 2022 Oct 26;2022:2988334. doi: 10.1155/2022/2988334. Available at: https://www.who.int/publications/i/item/who-report-on-cancer-setting-priorities-investing-wisely-and-providing-care-for-all (Acesseced November 13, 2020). 1889 pesos $ 1.889. 60, 619–642. Cytotechnology 43 (1–3), 149–154. The mechanism of action reported in in vivo studies involves slightly more complex processes. Carvacrol es un químico que contiene propiedades de calentamiento. Beyond the Semi-synthetic Artemisinin: Metabolic Engineering of Plant-Derived Anti-cancer Drugs. O timol é amplamente utilizado como um antibacteriano, antimicrobiano e antifúngico. 2 (6), a001198. p38 MAPK Signaling Mediates Mitochondrial Apoptosis in Cancer Cells Induced by Oleanolic Acid. Its inhibition induces a pronounced anticancer activity (Li et al., 2016). Los detectores de fluorescencia tienen la capacidad de medir señales de luz muy débiles comparados con los detectores de absorción UV tal como el DAD 8. Isolation and Identification of Volatile oils from Iraqi Thyme ( Thymbra Spicata ) and study the antimicrobial activity. Para P. aeruginosa e M. pachydermatis, os valores de MIC90 variaram de 0,09 a 0,25% (800-2,292 μg/mL). De La Chapa et al. doi:10.1016/j.bmcl.2018.06.044, Marullo, R., Werner, E., Degtyareva, N., Moore, B., Altavilla, G., Ramalingam, S. S., et al. Germany: CABI. 3 (4), 294–300. Este compuesto es insoluble en agua pero soluble en disolventes orgánicos como etanol y éter dietílico, acetona. doi:10.4149/BLL_2020_016, Elshafie, H., Armentano, M., Carmosino, M., Bufo, S., De Feo, V., and Camele, I. Evaluación del uso de los aceites esenciales como alternativa al uso de antibióticos promotores de crecimiento en pollos de engorde. National Journal of Chemistry; 2005;18: 289-298. 8 (3), 963–971. J. Gastroenterol. 50 (1), 271–276. doi:10.1016/j.otohns.2004.09.050, Llana-Ruiz-Cabello, M., Gutiérrez-Praena, D., Pichardo, S., Moreno, F. J., Bermúdez, J. M., Aucejo, S., et al. The antiproliferative activity of carvacrol was 1.2 times higher against MDA-MB231 cells compared to U87 cells (Baranauskaite et al., 2017). Cien aislados bacterianos y fúngicos, incluyendo Staphylococcus pseudintermedius susceptible a meticilina (n = 10), S. pseudintermedius resistente a meticilina (n = 10), Streptococcus sp. Resultados: Life Sci. The Essential Oil of Cymbopogon Citratus Stapt and Carvacrol: An Approach of the Antitumor Effect on 7,12-Dimethylbenz-[α]-Anthracene (DMBA)-Induced Breast Cancer in Female Rats. En cuanto a las propiedades físicas de este compuesto, tiene el distintivo olor acre y cálido del orégano. J Microbiol Biotechnol. Se utilizó la hidrodestilación con trampa de Clevenger. doi:10.1016/S1470-2045(18)30094-9, Whitfield, J. 4. Cancer Lett. J. Cytotoxic, Cytogenetics and Immunomodulatory Effects of Thymol from Thymus Vulgaris on Cancer and Normal Cell Lines In Vitro and In Vivo. Un poco de aceite de orégano en la dieta también apoya la pérdida de grasa corporal no deseada. According to De La Chapa et al. 8600 Rockville Pike Lett. doi:10.1016/j.fct.2013.08.037, Pernas, S., Tolaney, S. M., Winer, E. P., and Goel, S. (2018). Toxicol. (2020) and Sisto et al. Our results showed that 24.6% of in vitro studies (n = 17) and 10% of in vivo studies showed an increase in Bax levels after treatment with carvacrol or thymol. 背景: 多重耐药菌的抗菌治疗是一项全球均需面临的重要挑战,并且其经常使犬外耳炎复杂化。 假设/目的: 研究牛至油、百里香油及其主要酚类成分,对细菌和真菌引起的犬外耳炎的体外疗效。与精油相比,推测主要酚类成分具有更高的抗菌活性。 方法和材料: 使用肉汤微量稀释和点镀技术进行药敏试验,以确定最小抑菌、杀菌和杀真菌浓度(MIC、MBC和MFCs)。采用时间-杀菌动力试验以确定精油及其酚类成分的杀菌和杀真菌活性。共选取从犬外耳炎中分离的100株细菌和真菌菌株,包括甲氧西林敏感(n = 10)和甲氧西林耐药(n = 10)的假中间型葡萄球菌、β-溶血性链球菌(n = 20)、铜绿假单胞菌(n = 20;包括对一种或两种抗生素耐药的10个菌株)、奇异变形杆菌(n = 20)和厚皮马拉色菌(p = 20)。 结果: 牛至油、百里香油、香芹酚和百里香酚对所有检测的细菌和真菌菌株均有抗菌活性。对于革兰氏阳性菌和奇异变形杆菌,MIC90 值范围为0.015-0.03%(146-292μg/ mL);对于铜绿假单胞菌和厚皮马拉色菌,MIC90 的数值范围为0.09-0.25%(800-2292μg/ mL)。 结论和临床意义: 牛至油、百里香油、香芹酚和百里香酚对100株犬外耳炎菌株(其中还包括一些高度耐药的菌株),均有良好的体外杀菌和杀真菌活性。精油及其主要酚类成分治疗犬外耳炎的效果,需要进行更多的体内试验来获得。. Se adapta muy bien a los valles interandinos sobre los 2600 m.s.n.m. It was revealed in the study by Hassan et al. The viability of MCF-7 cells was reduced after carvacrol treatment (200 μmol/L), with a significant increase in the number of early and late apoptotic cells, accompanied by a negative regulation of Bcl2 and positive regulation of Bax protein. 55 (3), 273–279. mirabilisの0.015〜0.03%(146〜292μg/ mL)の範囲にわたった。 緑膿菌およびM. doi:10.1078/094471103322004785, Zhai, C.-L., Tang, G.-M., Qian, G., Hu, H.-L., Wang, S.-J., Yin, D., et al. O'Donnell, J. S., Massi, D., Teng, M. W. L., and Mandala, M. (2018). Os benefícios medicinais do óleo essencial de orégano foram utilizados para tratar doenças pulmonares, bronquite, sinusite e tosses. (2018) demonstrated that the cytotoxicity exhibited by carvacrol against HeLa cells occurred through the suppression of the cell cycle and induction of apoptosis, the latter accompanied by an increase in caspase-9, PARP cleavage, and activation of ERK, increasing the expression of phospho-ERK1/2. Methods and materials: Chin. doi:10.1177/1934578x1200701201, Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., et al. Copyright © 2021 Sampaio, Pina, Serafini, Tavares and Guimarães. 35 (2011), 735–742. A., and Jeyasekharan, A. D. (2019). Berlin: Springer, 185–232. In addition, the induction of apoptosis in both cell lines occurred in a concentration-dependent manner (Elbe et al., 2020). The Middle Ages. doi:10.1016/j.ejphar.2011.08.017, Huang, H., Zhang, X.-F., Zhou, H.-J., Xue, Y.-H., Dong, Q.-Z., Ye, Q.-H., et al. Physiol. Cell cycle involvement in cancer treatment with carvacrol and thymol. H. Hajimehdipoor, M. Shekarchi, M. Khanavi, N. Abid, M. Amri, A validated high performance liquid chromatography method for the analysis of thymol and carvacrol in Thymus vulgaris L. volatile oil. Open Chem. Curr. 79 (6), 1019–1031. Structure and Function of Matrix Metalloproteinases and TIMPs. El carvacrol es un compuesto orgánico que tiene la fórmula química C10H14O. We used the Kappa statistical test to measure the inter-rater reliability (Landis and Koch, 1977). doi:10.1002/med.21574, Wullschleger, S., Loewith, R., and Hall, M. N. (2006). Curr. El método de determinación es adecuado para la cuantificación del timol y carvacrol en muestras de hojas de orégano secadas al aire bajo sombre y extraÃdos por el método de Klevenger durante 2 horas. El timol pertenece al grupo de los terpenos. 19 (2), 309–323. (2005). (2018). Chin. Caspases and Cancer. In a way, it can be seen that the studies in this area do not seem to evolve toward a specific target, with low complementarity of the screenings carried out in vitro for the studies developed with experimental animals. Patógenos multirresistentes representam um grande desafio global na terapia antimicrobiana e frequentemente complicam otites externas em cães. Both are monoterpenoid phenols, the main components present in essential oils obtained from several plant species of the Lamiaceae and Verbenaceae families, such as oregano (Origanum vulgare L.), thyme (Thymus vulgaris L.) and “alecrim-da-chapada” (Lippia gracilis) (Santos et al., 2016; Salehi et al., 2018; Sharifi-Rad et al., 2018; Baj et al., 2020), which have already been reported to exhibit beneficial effects against many diseases (Silva et al., 2018), including cancer (Elbe et al., 2020; Pakdemirli et al., 2020). Med. 181 (6), 1895–1899. 15 (4), 339–351. Figure 2 shows a summary of the main effects observed in the in vivo studies. I. S. Al-Sheibany, K. H. Kadeem, A. S. Abdullah. The 400–600 μM range of concentrations promoted cell necrosis and the 800 μM concentration killed all cultivated cells (Hsu et al., 2011). Asian Pac. Drug Resist. Liolios, O. Gortzi, S. Lalas, J. Tsaknis, I. Chinou; Liposomal incorporation of carvacrol and thymol isolated from the essential oil of Origanum dictamnus L. and in vitro antimicrobial activity. 105, 652–661. Em Portugal, o óleo essencial é conhecido como óleo de orégão e em países de língua inglesa como oregano oil. J. Cel Physiol. (2016) reported that carvacrol effectively inhibited cell proliferation through the negative regulation of CCND1 and CDK4 expression, and the positive regulation of p21 expression, resulting in a significant decrease of cells in the S phase, in addition to inhibiting the migration and invasion abilities of Tca-8113 cells via phospho-focal adhesion kinase (p-FAK), p-catenin, ZEB1 and MMP-2 and -9 reduction. The pre- and post-treatment with carvacrol in animals with liver cancer induced by diethylnitrosamine (DEN) revealed a decrease in the number of nodules, a final body weight increase and a reduction in liver weight. Bioorg. doi:10.1016/j.cell.2006.01.016, Yeh, J.-H., Chou, C-T., Chen, I-S., Lu, T., Lin, K-L., Yu, C-C., et al. Código: 2173e Ingredientes: Aceite de orégano silvestre (Origanum vulgare) Al considerar las propiedades físicas de este compuesto, tiene el característico olor acre y cálido del orégano. Os efeitos citotóxicos do carvacrol podem fazer dele um agente antisséptico e antimicrobiano efectivo. Carvacrol Induces Mitochondria-Mediated Apoptosis in HL-60 Promyelocytic and Jurkat T Lymphoma Cells. Cytotechnology 64 (1), 43–51. (2021) that the administration of thymol (20 mg/kg/day, p. In relation to thymol, there were concentration-dependent cytotoxic effects and interruption of the cell cycle progression in the G0/G1 phase in P-815 cells (Jaafari et al., 2012). Treatment with carvacrol (100 μM) showed early and late apoptotic cells accompanied by a reduction of mitochondrial membrane potential levels, suggesting that apoptosis was mediated by the mitochondrial pathway, with a significant increase of Bax pro-apoptotic proteins, decreased expression of the anti-apoptotic proteins Bcl2 and an increased caspase-3 protein level (Bhakkiyalakshmi et al., 2016). Um teste em laboratório demonstrou que estes óleos do orégano, e carvacrol em particular inibem o desenvolvimento de Candida albicans funcionando mais efetivamente se aplicado juntamente com um agente antifúngico chamado caprylate . β-hemolítico (n = 20), Pseudomonas aeruginosa (n = 20; incluidos 10 aislamientos resistentes a uno o dos antimicrobianos), Proteus mirabilis (n = 20) y Malassezia pachydermatis (n = 20) de perros con otitis externa. The Measurement of Observer Agreement for Categorical Data. Se preparó diferentes concentraciones a partir de la solución stock (0,6 - 18 ìg/mL de timol y 0,06 1,8 ìg/mL para carvacrol); se plateó la curva de calibración. Epub 2019 May 21. Expression of Bcl-2 and P53 in Induction of Esophageal Cancer Cell Apoptosis by ECRG2 in Combination with Cisplatin. doi:10.1007/s10616-013-9547-5, Ayude, D., Fernández-Rodríguez, J., Rodríguez-Berrocal, F. J., Martínez-Zorzano, V. S., De Carlos, A., Gil, E., et al. There was also an induction of apoptosis with a reduction of Bcl-2 protein levels, and an increase in Bax, caspase-3 and -9 protein levels, besides the production of ROS. Timol: es un antigúngico natural que puede ayudar y mejorar al sistema inmunológico que puede proteger contra las toxinas que pueden atacar al organismo. Methoden und materialien: Our review also showed that carvacrol and its thymol isomer are capable of restraining growth and combating different tumor strains in vitro. doi:10.1007/s11094-019-01961-w, Shalini, S., Dorstyn, L., Dawar, S., and Kumar, S. (2015). Biometrics 33 (1), 159–174. Anti-proliferative and Pro-apoptotic Effect of Carvacrol on Human Hepatocellular Carcinoma Cell Line HepG-2. The initial search resulted in 1,170 records, of which 594, 169, 194, and 213 were found in PubMed, Web of Science, Scopus and Lilacs, respectively. J. Farmacogn. 79, 205–210. Comparación lado a lado: carvacrol frente a timol en forma tabular 5. Remarkably, ten studies did not report the source of the tested compounds. ltellez@lamolina.edu.pe 2 Molinos Cusco SA, Kilometro 76, Cusipata, Quispicanchi, Cusco 3 Instituto de Investigación en BioquÃmica y BiologÃa Molecular de la UNALM Lima Perú. Dis. J. La apicultura y el timol El timol como aceite esencial es muy usado el la apicultura y la cría de abejas, esto debido a que este aceite esencial es usado para combatir organismos más . Carvacrol Targets AXL to Inhibit Cell Proliferation and Migration in Non-small Cell Lung Cancer Cells. IC50 values determined 24 h after the incubation of the studied cells with carvacrol or thymol were compiled, submitted to the standardization of the unit (μM) (Supplementary Table S2) and were expressed as mean ± standard error of the mean (SEM). 11 (4), 2619–2624. Se tomó 1000 g de material fresco de hojas de O. vulgare. National Center for Biotechnology Information. Cardiovasc. (2020) reported that high doses of thymol can act on cancerous and healthy cells, while low doses seem to protect healthy cells but harm cancer cells. RESUMEN. Horváthová, E., Sramková, M., Lábaj, J., and Slamenová, D. (2006). Hence, positive expression of caspases increases tumor sensitization to treatment (Hensley et al., 2013) (Figure 6). 132 (3), 395–400. Según la FEN, "entre las sustancias activas presentes en los aceites esenciales del orégano se encuentran los compuestos fenólicos timol y carvacrol con actividad antimicrobiana". doi:10.1080/01480545.2018.1538233, Giardina, M. G., Matarazzo, M., Varriale, A., Morante, R., Napoli, A., and Martino, R. (1992). Inhibition of TRPM7 by Carvacrol Suppresses Glioblastoma Cell Proliferation, Migration and Invasion. Se obtuvo una recuperación máxima de carvacrol y timol de 98,68 % y 90,95 % respectivamente para los dos niveles. (2012) revealed that the latter was more sensitive to thymol effects, resulting in the accumulation of cells in the G0/G1 phase. Int. Bratisl Lek Listy 121 (2), 122–128. Rev. Possui propriedades antissépticas, sendo um desinfetante mais eficaz que o ácido carbólico. On the other hand, AFU indicates clinical prognosis of several malignant tumors and helps to diagnose primary hepatocarcinoma (Giardina et al., 1992), colorectal cancer (Ayude et al., 2000), ovarian cancer (Abdel-Aleem et al., 1996), and was recently identified as an effective new biomarker for squamous cell carcinoma of the early esophagus (Yu et al., 2019). Food Sci. Cancer Res. The selected studies were carried out in different countries: India (n = 14), China (n = 14), Turkey (n = 13), the Republic of Korea (n = 5), Slovakia (n = 5), Iran (n = 5), Morocco (n = 2), Brazil (n = 2), Greece (n = 2), Iraq (n = 2), The United States of America (n = 2), Canada (n = 2), Egypt (n = 2), Croatia (n = 1), Lithuania (n = 1), Italy (n = 1), Spain (n = 1), The United Kingdom (n = 1), Peru (n = 1), Belgium (n = 1). Oncol. Almost all studies did not present enough data to allow the judgment of the domains related to the generation of the random sequence, concealment of the allocation, blinding of the researchers and evaluators of the results. Tesis de MagÃster en Producción Animal, lÃnea de profundización en nutrición de monogástricos. ¿Cuál es la diferencia entre carvacrol y timol. Accessibility Role of Fruit and Vegetable in the Treatment of Cancer. Regulation of C6 Glioma Cell Migration by Thymol. Asian Pac. En general, el orégano es una planta medicinal muy beneficiosa para afecciones del aparato respiratorio debido a su efecto antiinflamatorio, analgésico y antiséptico. The antiproliferative effect was confirmed by Govindaraju and Arulselvi (2018), who reported marked cell cycle arrest, attested by the accumulation of G1 phase cells, a reduction in the number of G2/M cells and apoptosis through the mitochondria-mediated pathway and PARP cleavage/activation, together with a reduced expression of the anti-apoptotic protein Bcl-2. Medicinal Plants of the World. doi:10.1038/sj.onc.1208244, Srinivas, U. S., Tan, B. W. Q., Vellayappan, B. Carvacrol y Timol de Orégano $ 281.00 -Trata infecciones respiratorias -Es un fuerte antibiótico natural -Atiende afecciones en la piel -Ayuda a combatir síntomas de la gastritis ESTAFILOFin ® Añadir al carrito Categoría: Cápsulas / tabletas Descripción Cápsulas 30 cáps. Health 34 (8), 525–539. official website and that any information you provide is encrypted Al navegar en nuestro sitio aceptas que usemos cookies para personalizar tu experiencia según la Declaración de Privacidad. doi:10.1016/j.lfs.2012.03.027, Lim, W., Ham, J., Bazer, F. W., and Song, G. (2019). 10, 521–532. The .gov means it’s official. MATÉRIELS ET MÉTHODES: La sensibilité antimicrobienne a été testée par microdilution sur plaque pour déterminer la concentration minimale inhibitrice et les concentrations bactéricides/fongicides (MICs, MBCs et MFCs). After screening the title and abstract, 706 reports were excluded, and 1 report was sought for retrieval, as it met the criteria after reading the full text, resulting in 77 studies. In-vitro Evaluation of Apoptotic Effect of OEO and Thymol in 2D and 3D Cell Cultures and the Study of Their Interaction Mode with DNA. They are also important components of the oregano oil. La diferencia clave entre carvacrol y timol es que el carvacrol contiene un grupo hidroxilo en la posición orto del anillo de benceno, mientras que el timol contiene un grupo hidroxilo en la posición meta del anillo de benceno ... La siguiente infografía tabula más diferencias entre carvacrol y timol. The Staphylococcus aureus bacterium is one of the most . After 6 weeks, they found that the average number of tumor nodules on the lung surface of the two treatment groups was significantly lower, revealing an anti-metastatic effect, probably due to the inhibition of the Wnt/β-catenin signaling pathway (Zeng et al., 2020). A hipótese foi de que os principais componentes fenólicos teriam maior atividade antimicrobiana quando comparados com o óleo essencial relativo. doi:10.1590/S0102-695X2012005000021, Jabłońska-Trypuć, A., Matejczyk, M., and Rosochacki, S. (2016). In a rat neuroblastoma (N2a cell line), treatment with carvacrol (200–400 mg/L) exhibited cytotoxic and antiproliferative effects, along with antioxidant activity (Aydın et al., 2014). (2015). doi:10.1016/j.ajpath.2012.08.044, Silva, E. R., de Carvalho, F. O., Teixeira, L. G. B., Santos, N. G. L., Felipe, F. A., Santana, H. S. R., et al. Conclusions: Carvacrol and thymol exhibited antitumor and antiproliferative activity through several signaling pathways. The PRISMA 2020 Statement: an Updated Guideline for Reporting Systematic Reviews. These effects seem to be related to the oxidative damage observed after the increase of ROS levels (Satooka and Kubo, 2012). In this sense, anticancer therapies can follow two paths; using compounds that prevent the formation of ROS, and thereby preventing carcinogenesis; or using compounds that have as their action mechanism the increase of ROS, promoting oxidative stress within the tumor (de Sá Junior et al., 2017). El orégano es rico en antioxidantes, que pueden ayudar a neutralizar los radicales libres y reducir la inflamación. longevity 2017, 2467940. doi:10.1155/2017/2467940, Deb, D. D., Parimala, G., Saravana Devi, S., and Chakraborty, T. (2011). 3 (2), 307–312. 2), 44–47. 4. Chemotherapy-associated Oxidative Stress: Impact on Chemotherapeutic Effectiveness. Todos os direitos reservados. J. In murine B16-F10 and A375 melanoma cell lines, carvacrol reduced cell viability and induced cytotoxicity (Satooka and Kubo, 2012; Ferraz et al., 2013; Govindaraju and Arulselvi, 2018). Only 4.3% (n = 3) of the studies recorded reported randomness when taking photos of selected areas regarding apoptotic activity assays. Instituto de Salud Pública. Summary of main effects observed in in vivo studies. Further studies are needed to clarify this issue. Enzyme Inhib. 65, 17–24. El carvacrol inhibe el crecimiento de diversas cepas de bacterias por ejemplo Escherichia coli [5] y Bacillus cereus.Se utiliza de aditivo alimentario para prevenir la contaminación bacteriana. (2019). Oreganoöl, Thymianöl, Carvacrol und Thymol zeigten eine antibakterielle Aktivität gegenüber allen getesteten bakteriellen und mykologischen Isolaten. doi:10.1533/9781845694296.4.272, Aydın, E., Türkez, H., and Keleş, M. S. (2014). doi:10.1016/j.semcancer.2017.04.015, Olsson, M., and Zhivotovsky, B. Regulatory Roles of MAPK Phosphatases in Cancer. longevity 2016, 1404505. doi:10.1155/2016/1404505, Collins, T. S., and Hurwitz, H. I. Development of chitosan-based biodegradable films enriched with thyme essential oil and additives for potential applications in packaging of fresh collard greens. doi:10.1016/s0959-8049(00)00297-5, Krelin, Y., Zhang, L., Kang, T.-B., Appel, E., Kovalenko, A., and Wallach, D. (2008). doi:10.1038/nrc1187, Seresht, H. R., Albadry, B. J., Al-mosawi, A. K. M., Gholami, O., and Cheshomi, H. (2019). El envío gratis está sujeto al peso, precio y la distancia del envío. Biol. Through in vitro studies, we found that carvacrol proves to be more potent than thymol, and appears to have a greater cytotoxic effect for some cell lines, such as carcinomas (prostate and stomach) (Khan et al., 2017; Günes-Bayir et al., 2018; Khan et al., 2019). Natural Products: an Evolving Role in Future Drug Discovery. Natural Compounds as Modulators of Cell Cycle Arrest: Application for Anticancer Chemotherapies. Tesis MaestrÃa en Ciencias QuÃmica Universidad Nacional de Colombia; 29 - 30, 2012. (2015) reported that the average lethal dose of carvacrol after intravenous administration in dogs was 310 mg/kg, for rats it was 810 mg/kg when administered orally and 80 and 73 mg/kg when injected intravenously or intraperitoneally, respectively. Sci. Fiandalo, M. V., and Kyprianou, N. (2012). DNA-protective Effects of Two Components of Essential Plant Oils Carvacrol and Thymol on Mammalian Cells Cultured In Vitro. doi:10.1002/cam4.1976, Luo, Y., Wu, J.-Y., Lu, M.-H., Shi, Z., Na, N., and Di, J.-M. (2016). doc.documentElement.appendChild(s); 12. (2018) also reported decreased viability of HeLa cells and induction of apoptosis by PARP cleavage, suggesting that the anticancer effect of thymol is caused by mitochondrial dysfunction and subsequent apoptosis. Cyclin-dependent Kinase (CDK) 9 and 4/6 Inhibitors in Acute Myeloid Leukemia (AML): a Promising Therapeutic Approach. In addition, carvacrol showed a greater cytotoxicity compared to thymol against murine mast cell cells (P-815 cell line) (Jaafari et al., 2007; Jaafari et al., 2012), with accumulation of cells in the S phase (Jaafari et al., 2012). (2020) showed a better effect of carvacrol at a dose of 100 mg/kg/day compared to the other doses tested (50 and 200 mg/kg/day) in female Holztman rats with breast cancer induced by 7,12-dimethylbenzanthracene (DMBA), showing a reduction of 4 (of 16) tumors, in addition to a 75% reduction in the frequency of tumors, a 67% reduction in incidence, an increase in tumor latency and a reduction in the average tumor volume and cumulative tumor volume (Rojas-Armas et al., 2020). 2. sifat anti-inflamasi Para ilmuwan dari Jerman dan Swiss mengidentifikasi bahan aktif di oregano, yang dikenal sebagai beta-caryophyllin (E-BCP), yang dapat membantu mengobati gangguan seperti osteoporosis dan arteriosklerosis. Hosp. Biophysical Res. The Bioactivity and Toxicological Actions of Carvacrol. Para P. aeruginosa y M. pachydermatis, los valores de MIC90 variaron de 0,09 a 0,25% (800-2,292 μg/mL). As for the lung metastasis model, HCT116 cells were injected into the tail vein of each mouse and then received treatment with thymol (75 or 150 mg/kg every other day). Ingresa a tu cuenta para ver tus compras, favoritos, etc. Las soluciones Stock de timol (3 mg/mL) y carvacrol (0,3 mg/mL) fueron preparadas separadamente con una mezcla de solventes ACN:H2O (80:20). (2015). doi:10.1016/j.cardiores.2005.12.002. The P53 Pathway: Positive and Negative Feedback Loops. The Mechanism of Carvacrol-Evoked [Ca2+]i Rises and Non-ca2+-triggered Cell Death in OC2 Human Oral Cancer Cells. HIPÓTESIS/OBJETIVOS: Se investigó la eficacia in vitro del aceite de orégano, el aceite de tomillo y sus principales componentes fenólicos contra los aislados bacterianos y fúngicos asociados con la otitis externa canina. Effect of Thymol on Ca2+ Homeostasis and Viability in Human Glioblastoma Cells. Bogotá Colombia. Anti-proliferative and Pro-apoptotic Activity of Carvacrol on Human Cancer Cells. (2013). Natural Products as Leads to Anticancer Drugs. (2020). There is, therefore, an ongoing search for substances that can be used to develop more effective treatments, with less side effects, to use against cancer; one promising group of substances are natural products (NPs). Epidemiological study of dogs with otitis externa in Cape Breton, Nova Scotia. doi:10.1111/jcmm.13661, Li, H., Hu, J., Wu, S., Wang, L., Cao, X., Zhang, X., et al. Caspase Control: Protagonists of Cancer Cell Apoptosis. Se secó a temperatura ambiente en sombra, obteniéndose 200 g de hojas secas. Av. Elimina Cándida. Caspases are central apoptosis regulators and executors, and thus attractive targets for the development of therapeutic strategies for cancer treatment (Ghavami et al., 2009; Hensley et al., 2013; Fiandalo and Kyprianou, 2012; Shalini et al., 2015). O carvacrol pode ser sintetizado pela fusão de cimol-ácido sulfónico com potassa cáustica; pela acção do ácido nitroso sobre 1-metil-2-amino-4-propil benzeno; pelo aquecimento prolongado de cinco partes de cânfora com uma parte de iodo; ou aquecendo carvol com ácido fosfórico glacial ou ainda por meio de desidrogenação de carvona com um catalisador Pd/C. Thymol Reduces Acetic Acid-Induced Inflammatory Response through Inhibition of NF-kB Signaling Pathway in Rat colon Tissue. Am. Pediatr. Conheça os benefícios, efeitos colaterais e propriedades medicinais do óleo de orégano, composto ácido rosmarínico, carvacrol, timol e outras substâncias. Cuantificación por CromatografÃa LÃquida de Alta Resolución. J. National Library of Medicine. (1996). [13] con modificaciones. 60 (5), 275–283. Res. J. Prev. Systemic Chemotherapy in Advanced Pancreatic Cancer. Gaia Herbs Oil of Oregano - Immune and Antioxidant Support Supplement to Help Sustain Overall Well-Being - with Oregano Oil, Carvacrol, and Thymol - 60 Vegan Liquid Phyto-Capsules (30-Day Supply) 60 Count (Pack of 1) 4.7 (8,109) $2239 ($0.37/Count) $20.15 with Subscribe & Save discount. Pharmacol. (2021) demonstrated the potential of these monoterpenes in the control of gastric carcinoma by reducing the viability of AGC cells. (2004). No use, distribution or reproduction is permitted which does not comply with these terms. 38 (1), 279–286. outline: none; Regarding in vivo studies, the pretreatment with carvacrol in colon cancer (Sivaranjani et al., 2016) and hepatocellular carcinoma (Jayakumar et al., 2012) increased the levels of enzymatic antioxidants such as GPx, SOD, CAT, GR, and GSH, revealing a chemopreventive effect of carvacrol and prevention of cell proliferation (Jayakumar et al., 2012; Sivaranjani et al., 2016). The cell cycle consists of four discrete phases in which the cell increases in size and cellular content is duplicated (gap 1 or G1 phase), DNA is replicated (synthesis, or S phase), it prepares to divide (gap 2, or G2 phase), and then divides, creating two identical daughter cells (mitosis, or M phase). Activation and Signaling of the P38 MAP Kinase Pathway. Sobre Nosotros, Diferencia entre policarbonato y plexiglás. 580 (21), 4984–4990. doi:10.1165/rcmb.2005-0280OC, Zhang, L., Yu, J., Park, B., Kinzler, K., and Vogelstein, B. Bras. Bethesda, MD 20894, Web Policies HYPOTHÈSES/OBJECTIFS: Nous avons étudiés l'efficacité in vitro de l'huile d'origan, de l'huile de thym et de leurs principaux composés phénoliques, contre les souches bactériennes et fongiques associées aux otites externes canines. The knowledge obtained through the reviewed studies provides strong evidence of the antitumor and antiproliferative activity promoted by carvacrol and thymol. Carvacrol Alleviates Prostate Cancer Cell Proliferation, Migration, and Invasion through Regulation of PI3K/Akt and MAPK Signaling Pathways. 38 (4), 263–355. In fact, TP53 genetic alterations are commonly observed in clinical tumor samples, since most mutations lead to function loss, in which cells can escape the destruction and repair process, resulting in a malignant transformation through favorable natural selection (Olsson and Zhivotovsky, 2011). Neoplasma 54 (2), 108–112. (2002). Carvacrol Modulates Instability of Xenobiotic Metabolizing Enzymes and Downregulates the Expressions of PCNA, MMP-2, and MMP-9 during Diethylnitrosamine-Induced Hepatocarcinogenesis in Rats. doi:10.18632/oncotarget.6516, Li, L., He, L., Wu, Y., and Zhang, Y. Ind. O uso é contraindicado durante a gravidez. s.text ='window.inDapIF = true;'; Por favor, vuelve a intentarlo. Phytomedicine 17 (8–9), 581–588. doi:10.1016/j.bbrc.2015.04.030, Arunasree, K. M. (2010). The Mitochondrial Death/life Regulator in Apoptosis and Necrosis. 448 (5), 237–249. O óleo de orégano é obtido através da planta Origanum vulgare, nativa do Mediterrâneo. la determinación de timol y carvacrol en muestras de orégano y otras plantas, ha sido realizado por muchos autores utilizando métodos por hplc 1-5 y cromatografía de gases con detector fid o de masas. (2018). To assess the risk of bias in in vivo studies, the SYRCLE Risk of Bias tool was used, and for in vitro studies, a modified version was used. Turk J. Med. (2018). They were mostly obtained commercially, provided by Sigma Aldrich (n = 52), Fluka (n = 5), Aldrich Chemical (n = 2), Western Chemical (n = 1), Agolin SA (n = 1), Alfa Aesar (n = 1). Pathol. species (Martino et al., 2018). World J. Pharm. El grupo hidroxilo está en posición para con respecto al grupo metilo y al grupo isopropilo. Ther. Assessment of in vitro studies risk of bias. 11 (9), 3980–3990. The expression of proapoptotic proteins, such as Bax (Li et al., 2017; Basu and Haldar, 1998), is an important mechanism of tumor regression (Backus et al., 2002). doi:10.1053/j.seminoncol.2004.09.026, Conklin, K. A. (2004). Es ampliamente estudiado debido a su amplia gama de aplicaciones clínicas. (2014) also evaluated the effect of carvacrol pre- and post-treatment on a DEN-induced hepatocarcinogenesis rat model and observed a stability in tumor marker levels, a reduced mast cell density and inhibition of cell proliferation. RÉSULTATS: L'huile d'origan, l'huile de thym, le carvacrol et le thymol ont montré une activité antibactérienne contre toutes les souches bactériennes et fongiques testées. doi:10.1016/B978-0-12-802215-3.00002-1, Shuman Moss, L. A., Jensen-Taubman, S., and Stetler-Stevenson, W. G. (2012). Tayarani-Najaran et al. 2011; 43 (1): 237-245. Carvacrol (500 and 1,000 μM) was able to inhibit the viability and proliferation of lung cancer cells (A549 cell line), in addition to inducing early apoptotic characteristics (Koparal and Zeytinoglu, 2003) and reducing the viability of the A549, H460 (Jung et al., 2018) and H1299 cells lines, the latter being resistant to epirubicin (Ozkan and Erdogan, 2012). For the colorectal cancer model, HCT116 xenograft was injected (i.p.) Food Chem. However, some studies have demonstrated the action of these compounds, in a negative way, in some normal cells, such as human fibroblast cells (WS-1; IC50 of 138.1 ± 8.7 μM of carvacrol (Günes-Bayir et al., 2018); breast epithelial cells (fR2; IC50 of 86 μg/mL of thymol; (Pathania et al., 2013), normal lymphocyte (PBMC; IC50 > 25 μg/ml of thymol; (Ferraz et al., 2013); rat embryonic fibroblasts (mild toxicity of 20.94% after thymol 5, 30.5, 61, 122, 244 ng/mL; (Abed, 2011). doi:10.1038/cdd.2014.216, Sharifi-Rad, M., Varoni, E. M., Iriti, M., Martorell, M., Setzer, W. N., Del Mar Contreras, M., et al. (2021). Potential and Use of Bacterial Small RNAs to Combat Drug Resistance: a Systematic Review. In contrast, 30% (n = 3) record random allocation of the animals in the study (Figure 4). Asia (51.9%) was the continent with the largest number of publications on the subject, followed by Europe (33.7%), the Americas (9.3%) and Africa (5.1%), with a greater trend of publications on this subject in the last three years (Supplementary Figure S1). However, the toxicity and side effects of many treatments can worsen the quality of life of these individuals (Weingart et al., 2018; Hassen et al., 2019; Lu et al., 2019). Epub 2019 Nov 15. Carvacrol es el fenol más abundante en el aceite de orégano. doi:10.4014/jmb.1506.06073, Karkabounas, S., Kostoula, O. K., Daskalou, T., Veltsistas, P., Karamouzis, M., Zelovitis, I., et al. El orégano (Origanum vulgare L.) es una planta aromática originaria del mediterráneo; tradicionalmente es cultivada en la zona sur del Perú. doi:10.2307/2529310, Lee, D. J., and Zeidner, J. F. (2019). 32 (9), 1688–1706. Pharmacother. Cel Biochem. O monoterpeno carvacrol (5-isopropil-2-metilfenol) está presente em muitos óleos essenciais de plantas, especialmente dos gêneros Origanum e Thymus, e tem atraído a atenção devido à sua grande variedade de atividades biológicas benéficas, como antibacteriana, antifúngica antioxidante e anestésica local. Es un fenol monoterpenoide. Pero es extremadamente soluble en disolventes orgánicos como los alcoholes. Aceite esencial de orégano: un potencial aditivo alimentario. Trends Mol. In vitro, esta sustancia muestra actividad antimicrobiana contra aproximadamente 25 cepas de bacterias periodontopáticas diferentes. in male Wistar rats provided promising protective activity against colon cancer by significantly reducing elevated serum levels of colon-related tumor markers, carbohydrate antigen 19-9 (CA 19-9) and carcinoembryonic antigen (CEA), as well as the apoptotic marker, caspase-3 compared to the colon cancer group. Pharmacognosy Magazine; 2010; 6 (23): 154-158. También podemos producir carvacrol sintéticamente mediante la fusión de ácido cymol sulfónico en presencia de potasa cáustica. var w = d.getElementsByTagName('script')[0]; Compromised MAPK Signaling in Human Diseases: an Update. Background: Cel Biochem. doi:10.1111/jcmm.12760, Zeng, Q., Che, Y., Zhang, Y., Chen, M., Guo, Q., and Zhang, W. (2020). 670 (1), 85–91. doi:10.1016/j.ejmech.2011.07.057, Nagase, H., Visse, R., and Murphy, G. (2006). carvacrol oregano emulsificado Ordenar por Más relevantes Aceite Esencial De Oregano Natier 30ml 70% Carvacrol 3140 pesos$3.140 Primal Fx Oregano Oil 80% Carvacrol Timol. (2013). J. Dr Behcet Uz Child. Oreganoöl, Thymianöl, Carvacrol und Thymol zeigten eine gute in vitro bakterizide und fungizide Aktivität gegenüber 100 Isolaten von Hunden mit Otitis externa, wobei einige hochresistente Isolate dabei waren. 89 (6), 867–882. 772, 92–98. doi:10.1186/s13643-016-0384-4, Ozawa, S., Shankar, R., Leopold, C., and Orubu, S. (2019). Depois de 24 horas, apenas se detectaram quantidades muito pequenas de carvacrol ou dos seus metabolitos na urina, indicando uma excreção quase completa ao fim de um dia. Management from Around the World. Similarly, Tayarani-Najaran et al. Sci. 14, 43. doi:10.1186/1471-2288-14-43, Horng, C.-T., Chou, C., Sun, T., Liang, W., Kuo, C., Wang, J., et al. Transl Oncol. Promocionado. (2017). University of Studies G. d'Annunzio Chieti and Pescara, Italy, Shenyang Pharmaceutical University, China. Human glioblastoma cells (DBTRG-05MG) showed reduced viability in a concentration-dependent manner when treated with carvacrol (200–600 μM), induced apoptosis and necrosis by ROS production and caspase-3 activity (Liang and Lu, 2012). Perry LR, MacLennan B, Korven R et al. High MMP-2 and -9 levels were associated with esophageal carcinomas (Koyama et al., 1990) and breast (Alrehaili et al., 2020), oral (Lin et al., 2004), bladder (Fouad et al., 2019), skin (Fundyler et al., 2004), larynx (Liu et al., 2005) cancer. Palabras clave: Aceite esencial, Timol, Carvacrol, Orégano, Origanum, HS-SPME-GC-MS. Recibido: 17/08/2020 Most studies have demonstrated the effect of these compounds on carcinomas, as they are one of the most common types of cancer (Neville, 2011). Carvacrol Timol 80% Antes: 1789 pesos$ 1.789 1520 pesos$ 1.520 15% OFF Mismo precio en 3x de $506,88 Primal Fx Oregano Oil 80% Carvacrol Timol. The present method has a linearity greater than 0.999, precision ≤ 2.27, 2.4 intra-day, and ≤ 2.47 and 1.94 for daily measurements for carvacrol and thymol respectively. 20 (3), 559–567. O orégano possui propriedades que ajudam a tratar algumas infecções, como gripes, infecções urinárias, herpes e candidíase, já que seus compostos, como o carvacrol, diminuem a atividade dos microrganismo que causam essas infecções, ajudando a curá-las de forma mais rápida e, por isso, pode ser indicado como complemento ao tratamento médico. (2016). At 200 μM, the MDA-MB-231 cell line was the most sensitive and MCF-7 was the least sensitive, indicating that the effectiveness of carvacrol may vary according to the types of breast cancer cell. Koss, B., and Greengard, O. (2016). PI3k belongs to a family of lipid kinases, involved in extracellular signals transduction and cell growth promotion (Wullschleger et al., 2006; Alzahrani, 2019). 5815 pesos $ 5.815. Reprod. doi:10.1016/j.phymed.2013.01.015. Anticarcinogenic and Antiplatelet Effects of Carvacrol. doi:10.1155/2016/1469693, Mari, A., Mani, G., Nagabhishek, S. N., Balaraman, G., Subramanian, N., Mirza, F. B., et al. 234 (2), 1803–1815. Debajo de esa altitud, la concentración de aceites esenciales (timol y carvacrol) disminuye. Med. Tomilho: veja para que serve a especiaria, Orégano: veja para que serve a especiaria, Candidíase: causas e tratamentos naturais, Remédios naturais para o tratamento da psoríase, O milho é considerado um dos alimentos mais, O chá de hibisco (Hibiscus sabdariffa) se to, Em estudos preliminares realizados em humanos, foi, O chá de hibisco é um dos chás mais popula, O morango é uma das frutas menos calóricas q, A curcumina é o principal ingrediente ativo do tu. (2018). Oncol. Moreover, genotoxic effects have been shown to be exhibited by carvacrol (Günes-Bayir et al., 2018) and thymol (Günes-Bayir et al., 2018), and it was also shown that a high concentration of carvacrol (460 µM) exhibited mutagenic and genotoxic effects causing DNA damage (Llana-Ruiz-Cabello et al., 2015). Carvacrol also promoted a decrease in Bcl-2, metalloproteinase-2 and -9 (MMP-2 and MMP-9), p-ERK, p-Akt, cyclin B1 levels and an increase in p-JNK, Bax levels, resulting in cell cycle arrest at the G2/M phase (Fan et al., 2015). FIGURE 2. doi:10.1016/j.canlet.2015.01.014, Bouhtit, F., Najar, M., Moussa Agha, D., Melki, R., Najimi, M., Sadki, K., et al. Entre las propiedades del orégano se ha visto que puede destruir bacterias o impedir su crecimiento. doi:10.1007/s10787-019-00583-8, Chan, H., Ho, J., Liu, X., Zhang, L., Wong, S. H., Chan, M., et al. La determinación del coeficiente (r2) se calculó por ajuste de mÃnimos cuadrados. doi:10.1049/iet-nbt.2014.0040, Mehdi, S., Ahmad, A., Irshad, M., Manzoor, N., and Rizvi, M. (2011). (2013). The methodological quality of the studies included revealed many items classified as “unclear” or “uncertain” indicating that the report—and presumably the experimental design—of these studies can be improved, especially with regard to the generation of the random sequence, the concealment of allocation and the blinding of researchers and evaluators, important factors in respect of a reliable result. doi:10.1007/s11010-014-2112-5, Suntres, Z. E., Coccimiglio, J., and Alipour, M. (2015). Plos Med. Carvacrol Alters Soluble Factors in HCT-116 and HT-29 Cell Lines. 90 (17–18), 703–711. In vitro antimicrobial effect of essential tea tree oil(. Molecules 25 (14), 3284. doi:10.3390/molecules25143284, Salehi, B., Mishra, A. P., Shukla, I., Sharifi-Rad, M., Contreras, M. d. M., Segura-Carretero, A., et al. doi:10.2174/1871520617666170327121228, Chen, W.-L., Barszczyk, A., Turlova, E., Deurloo, M., Liu, B., Yang, B. In a prostate cancer cell line (DU 145), carvacrol showed a significant reduction of cell viability and proliferation in a concentration and time dependent manner, marked by a cell cycle arrest, resulting in the accumulation of cells in the G0/G1 phase, and apoptosis, related to the increased activity of caspase-3, production of ROS and loss of mitochondrial membrane potential (Khan et al., 2017). Clin Infect Dis 2009; 48: 1-12. Opin. 16 (5B), 3053–3058. Chin. Caspase-9 as a Therapeutic Target for Treating Cancer. Pharm. Cell. J. Pharm. Toxicol. [4] Propiedades. RESULTADOS: el aceite de orégano, el aceite de tomillo, el carvacrol y el timol exhibieron actividad antibacteriana contra todos los aislamientos bacterianos y fúngicos probados. 55 (3), 206–211. It is of note that several studies suggested that signaling pathways (PI3K/AKT/mTOR and MAPKs) may be the main mechanism of action of these monoterpenoids, but more advanced studies are needed to elucidate this issue. *:focus-visible { This corroborated the findings of Wang et al. 10 (2), 174–180. Esta página foi editada pela última vez às 21h44min de 15 de janeiro de 2020. Auranofin-mediated Inhibition of PI3K/AKT/mTOR axis and Anticancer Activity in Non-small Cell Lung Cancer Cells. En particular, el carvacrol y el timol son dos compuestos del orégano que se han asociado con propiedades antivirales. 10. Puede detener el crecimiento de muchas bacterias en el organismo. doi:10.1016/j.ctrv.2016.03.002, Harris, S. L., and Levine, A. J. *Correspondence: Adriana Gibara Guimarães, adrianagibara@hotmail.com, adrianagibara@academico.ufs.br, Exploration of Natural Product Leads for Multitarget-Based Treatment of Cancer - Computational to Experimental Journey, View all
Antimicrobiano: Carvacrol es efectivo contra patógenos transmitidos por los alimentoscomo Escherichia coli, Salmonella y Bacillus cereus. New Drug 14, 3–14. Aceites que se mezclan bien con aceite de Orégano Es wurden Hemmstoffnachweise mittels Mikrodilutionsbouillon mit einer Spot- Plating Technik durchgeführt, um eine minimale Hemmstoffkonzentration und bakterielle/fungizide Konzentrationen (MICs, MBCs und MFCs) zu bestimmen. doi:10.1158/0008-5472.CAN-18-2738, Soung, Y. H., Lee, J. W., Kim, S. Y., Jang, J., Park, Y. G., Park, W. S., et al. β-hémolytique (n = 20), Pseudomonas aeruginosa (n = 20; comprenant 10 souches résistantes à un ou deux antimicrobiens), Proteus mirabilis (n = 20) et Malassezia pachydermatis (n = 20) de chiens avec otite externe. Para el timol, el lÃmite de detección determinado (LOD) es 0,0007 mg/L y el lÃmite de cuantificación (LOQ) es 0,002 mg/L. (2012). Toxicol. (2019), thymol produced cytotoxic effects and reduced the number of MCF-7 cells, suggesting that this monoterpene induces cell cycle arrest, probably due to p21 overexpression. Cancer Prev. Food Chemistry ; 2009; 112, (1): 7783. Toxicol. 360 (1–2), 51–60. PMC La precisión del método indica el grado de dispersión entre la determinación de la misma muestra. Un sinónimo de este compuesto es cymophenol. Como parte de las actividades del proyecto fue necesario el desarrollo de un protocolo para la cuantificación por HPLC para el cultivo de orégano. However, the enormous diversity of nature still holds many plant compounds without sufficient studies, particularly in the oncology area (Gordaliza, 2007; Asif, 2015). Med. Sci. Los lÃmites de detección determinado LOD y lÃmite de cuantificación LOQ fue de 0,0007 - 0,002 mg/L para el timol y 0,002 - 0,005 mg/L para el carvacrol, con una recuperación de 98,68 % y 90,95 %, respectivamente. 33 (7), 405–409. Study of Cytotoxic, Genotoxic and DNA-Protective Effects of Selected Plant Essential Oils on Human Cells Cultured In Vitro. A., and Bonner, W. M. (2017). It has powerful antioxidant, anti-inflammatory and antimicrobial effects. Antibiotic resistance profiles and activity of clove essential oil (. El timol, el carvacrol y la timohidroquinona son compuestos aromáticos del tomillo, el orégano y otras plantas de la familia de las lamiáceas.
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